Best Hemorrhoid Suppositories (2026): Preparation H, Anusol, Calmol 4 and NeilMed Ranked

The standard formula, from the brand that defines the shelf. Preparation H Hemorrhoid Suppositories, 12 count, pack of 2 combine phenylephrine HCl, a vasoconstrictor, with cocoa butter, a protectant, per the Drug Facts panel. The panel's Uses line reads temporary relief of the itching, burning and discomfort of hemorrhoids and temporary shrinking of swollen hemorrhoidal tissue; the second half is the phenylephrine, and it is why this is the product people reach for when the problem is internal swelling rather than external irritation. Directions on the label: adults, insert one suppository rectally up to 4 times daily, especially at night, in the morning and after each bowel movement; children under 12, ask a doctor.

What the label says to watch, and it is a longer list than a laxative's: ask a doctor before use if you have heart disease, high blood pressure, thyroid disease, diabetes or difficulty urinating due to an enlarged prostate, and ask a doctor or pharmacist if you take a prescription drug for high blood pressure or depression. Stop use and ask a doctor if bleeding occurs, if the condition worsens, or if it does not improve within 7 days. If pregnant or breastfeeding, ask a health professional before use. Owners consistently report the cocoa butter base softens in a warm bathroom; store cool and chill briefly before unwrapping if soft. Full write-up in our Preparation H suppositories review; the format question is settled in suppository vs cream for hemorrhoids.

More of the same, at the same price per unit. The Preparation H Hemorrhoid Symptom Treatment Suppositories, 48 count carry the same Drug Facts panel as the two-pack: phenylephrine HCl and cocoa butter, the same Uses line covering itching, burning, discomfort and swollen hemorrhoidal tissue, and the same directions of up to 4 times daily for adults with under 12 sent to a doctor. At $35.92 (verified via the Amazon Creators API on September 5, 2026) the box is about 75 cents each ($35.92 divided by 48), which is the two-pack's price exactly.

Everything else is identical to the pick: the heart, blood pressure, thyroid, diabetes and enlarged prostate ask-a-doctor lines, the stop lines for bleeding and worsening, and the pregnancy and breastfeeding ask-a-health-professional line. Storage matters more with a bigger box: cocoa butter softens in heat, so keep it in a cool cabinet, and see how to store suppositories if your bathroom runs warm.

The second brand, with a caveat about which Anusol you are getting. Anusol Suppositories, 12 per pack is the plainly titled listing at $12.90 (verified via the Amazon Creators API on September 5, 2026), which is about $1.08 each ($12.90 divided by 12). Anusol has been a hemorrhoid brand for decades, but the name is used on differently formulated products in the US and the UK, and the Amazon listing title as it stands states neither the actives nor the strengths. That is not a knock on the product; it is a reason to read the Drug Facts or pack panel before the first use rather than assuming it matches the Preparation H formula.

There is a second Anusol listing, Anusol Suppositories 12, at $24.82, nearly double the price for the same stated count; we list the cheaper one here and note the other exists. The stop lines on any OTC hemorrhoidal label are the same: bleeding, worsening, or no improvement within 7 days mean stop and ask a doctor, and pregnant or breastfeeding means ask a health professional first. Our brand write-up is the Anusol suppositories review, and the head-to-head is Preparation H vs Anusol.

The formula built on what the phenylephrine products leave out. Calmol 4 Hemorrhoidal Suppositories with Cocoa Butter and Zinc Oxide, 24 count state both actives in the listing title, and the title describes the pair as astringent protectant relief. Zinc oxide is the astringent, cocoa butter is the protectant and the base, and there is no vasoconstrictor. The label use is therefore the itching, burning, discomfort and irritation half of the hemorrhoid Uses line; the shrinking-swollen-tissue claim belongs to phenylephrine and does not appear here.

The general hemorrhoidal stop lines still apply: bleeding, worsening, or no improvement within 7 days mean stop and ask a doctor, under 12 is ask a doctor, and pregnant or breastfeeding is ask a health professional before use. Calmol 4 also sells a plainly titled 24 count at $24.12 and a 24 count 3-pack at $71.11; the 3-pack is about 99 cents each ($71.11 divided by 72) if you already know the formula suits you. The brand write-up is the Calmol 4 review, and Preparation H vs Calmol 4 puts the two formulas side by side.

A familiar name, a listing that leaves out the numbers. NeilMed Hemorrhoidal Suppositories carry a title that promises to shrink swollen tissue and relieve burning, itching and discomfort. The shrinking claim is the vasoconstrictor use line on an OTC hemorrhoidal label, which tells you what class of active to expect on the Drug Facts panel, but the title itself does not name it, and it does not state how many suppositories are in the box. At $10.99 (verified via the Amazon Creators API on September 5, 2026) it is the lowest box price here.

Because the title signals a vasoconstrictor, assume the phenylephrine ask-a-doctor lines until the panel says otherwise: heart disease, high blood pressure, thyroid disease, diabetes, enlarged prostate, and prescription drugs for blood pressure or depression. The stop lines are the same as every product here: bleeding, worsening, or no improvement within 7 days. Pregnant or breastfeeding, ask a health professional first. NeilMed's laxative and hemorrhoidal suppositories are covered together in our NeilMed suppositories review.

The suppository that is not a hemorrhoid drug. PROKTIS-M Rectal Suppositories state hyaluronic acid in the listing title, along with the descriptors natural and non-steroidal and the claim for healing of anus and rectum. We report that claim as the listing's, not ours. There is no vasoconstrictor, no astringent and no OTC monograph active, which means none of the phenylephrine warnings apply, and also that nothing on the pack is labeled to shrink swollen tissue or relieve itching in the way an OTC hemorrhoidal label is.

The stop rules do not change because the product is not a drug: rectal bleeding, worsening pain, or symptoms that last beyond a week are reasons to see a doctor regardless of what is in the cabinet. PROKTIS-M also appears in the best anal fissure treatments, where its healing positioning is discussed against the lidocaine and phenylephrine products, and the standalone write-up is the PROKTIS-M review.

Witch hazel, in the one format the big brands do not sell it in. WiseWays Herbals Witch Hazel Suppositories, 12 count are an herbal product from a small maker: witch hazel in a suppository base, 12 to the box per the listing title, with no drug actives and no Drug Facts panel. Witch hazel is the astringent in Tucks pads and Preparation H wipes, both of which are OTC drugs applied externally; this is the same botanical, taken internally, without the OTC label. At $20.60 (verified via the Amazon Creators API on September 5, 2026) that is about $1.72 each ($20.60 divided by 12).

Same house rule as every entry: bleeding, worsening, or symptoms beyond a week are a doctor's business, herbal suppository or not. Because it is a small-maker product, owners report batch-to-batch variation in firmness; store cool, and read what to do when a suppository has melted if a box arrives soft.

The other country's reference brand. Germoloids Suppositories x 12 is the UK's mainstream hemorrhoid line, available on Amazon US as an imported box of 12. The listing title states the count and nothing else: no actives, no strengths. Because it is a UK-market pack, its label follows UK conventions rather than the US Drug Facts format, and the directions and warnings on it are the ones that apply, so read the pack rather than assuming it mirrors a US label. At $18.21 (verified via the Amazon Creators API on September 5, 2026) that is about $1.52 each ($18.21 divided by 12).

The stop lines are universal regardless of label format: bleeding, worsening, or no improvement within 7 days mean see a doctor, and pregnant or breastfeeding means ask a health professional before use. For the US-labeled field with every active side by side, Preparation H vs Anusol covers the two brands most readers are actually deciding between.